GlycoSMART Platform

An unrivalled and integrated Glycochemistry platform based on the three following pillars:

CarboMimetics has developed a unique & proprietary platform – GlycoSMART– devoted to rationale & smart design, synthesis and optimization of sugar-based compounds (Glycochemistry Synthesis).

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GlycoFinder:

Tailored & comprehensive database, consolidating all existing and relevant sugar-based science for therapeutic purposes. Thanks to a smart correlation of consolidated data (diseases + potential targets + potential hits), GlycoFinder offers very promising perspectives of exploitation within new territories in terms of targets, molecules, patents, etc.

GlycoLib:

An exclusive collection of original small sugar fragments derived from natural polysaccharides (scheme 1) available for hit/lead determination and more than 3,000 building blocks (mono and oligosaccharide intermediates) available in our store for a novel fragment syntheses. Thanks to GlycoLib, process ranging from Hit identification to Lead is very significantly reduced by 3 to 5 years.

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Scheme 1: A process to identify natural small fragments and its pure synthetic derivatives with efficient activity on a specific target

Medicinal Chemistry:

Hit/Lead optimization process with improved pharmacodynamic and pharmacokinetic properties

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Scheme 2: Heparin drugs in thrombosis disease, a medicinal chemistry approach to get affinity and selectivity